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Test Code TPSF Protein, Total, Spinal Fluid

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

CSF


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge specimen to remove any cellular material.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 72 hours
  Frozen  180 days

Reference Values

≥12 months: 0-35 mg/dL

Reference values have not been established for patients that are <12 months of age.

Day(s) Performed

Monday through Sunday

CPT Code Information

84157

Clinical Information

Cerebrospinal fluid (CSF) proteins are those that remain in CSF following the ultrafiltration of plasma through the choroidal capillary wall. Some proteins that are unique to CSF are synthesized in the central nervous system. In general, diseases that interrupt the integrity of the capillary endothelial barrier lead to an increase in the total CSF protein.

 

CSF protein is generally increased in all types of meningitis, cerebral infarction, brain abscess, meningovascular syphilis, subarachnoid hemorrhage, some brain tumors, trauma to the brain, some cases of multiple sclerosis, encephalomyelitis, and degenerative neurologic diseases. A decreased CSF protein may occur in water intoxication, CSF leak (CSF rhinorrhea or otorrhea), and hyperthyroidism.

Report Available

Same day/1 to 2 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Method Name

Reflectance Spectrophotometry