Clinical Information

Fibrin monomers are intermediate products formed during the proteolysis of fibrinogen by thrombin. During intravascular coagulation, low levels of thrombin are available in the blood, but the quantity of fibrin monomers formed are not sufficient to aggregate and form a clot; instead, they associate themselves with fibrinogen or fibrinogen-degradation products to form soluble complexes (ie, soluble fibrin monomer complex). Disseminated intravascular coagulation (DIC)/intravascular coagulation and fibrinolysis (ICF), collectively termed DIC/ICF is a clinical diagnosis; no single test is completely sensitive or specific for DIC/ICF.