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HelpTest Code SKETC Ketones, Urine
Specimen Required
Container/Tube: Plastic urine container
Specimen Volume: 20 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Useful For
Screening for the presence of ketoacidosis
Method Name
Dipstick
Reporting Name
Ketone, QL, USpecimen Type
UrineSpecimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated | 72 hours |
Reject Due To
No specimen should be rejected.Clinical Information
The body normally metabolizes fats to carbon dioxide and water. Inadequate carbohydrate in the diet or defects in carbohydrate metabolism or absorption cause the body to metabolize fatty acids. Ketones (acetoacetic acid, acetone, and beta-hydroxybutyric acid) are produced during fat metabolism and are excreted in urine.
Patients with untreated or inadequately treated diabetes mellitus are unable to efficiently utilize glucose due to insufficient insulin. Under these conditions, large amounts of fatty acids are metabolized, and abnormal amounts of ketones are excreted in the urine (ketonuria).
Increased ketones may occur during physiological stress conditions such as fasting, starvation, pregnancy, strenuous exercise, fever, frequent vomiting, anorexia, and some inborn errors of metabolism.
Reference Values
Negative
Interpretation
Detection of ketones in the urine of a diabetic is significant and indicates a change in insulin dosage or other alteration in treatment is necessary.
Ketones may appear in urine in large amounts before serum ketone is elevated.
Cautions
False positive results (trace or less) may occur with highly pigmented urine specimens or those containing large amounts of levodopa metabolites. Compounds such as mesna (2-mercaptoethane sulfonic acid) that contain sulfhydryl groups may cause false positive results or an atypical color reaction.
Clinical Reference
1. Free HM: Modern Urine Chemistry Manual. Bayer Corp; 1996:47-49
2. Morton A: Review article: Ketoacidosis in the emergency department. Emerg Med Australas. 2020 Jun;32(3):371-376. doi: 10.1111/1742-6723.13503
Specimen Retention Time
2 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
81003
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SKETC | Ketone, QL, U | 50557-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| SKETC | Ketone, QL, U | 50557-8 |
Day(s) Performed
Monday through Sunday