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HelpTest Code OLIGS Oligoclonal Banding, Serum
Specimen Required
Only orderable as part of a profile. For more information see:
-OLIG / Oligoclonal Banding, Serum and Spinal Fluid
-MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Method Name
Only orderable as part of a profile. For more information see:
-OLIG / Oligoclonal Banding, Serum and Spinal Fluid
-MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid
Isoelectric Focusing (IEF) with IgG Immunoblot Detection
Specimen Type
SerumSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Clinical Information
The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. The detection of increased intrathecal immunoglobulin (Ig) synthesis is the basis for current diagnostic laboratory tests for MS. These tests include kappa free light chains in the cerebrospinal fluid (CSF) and CSF oligoclonal band (OCB) detection. Abnormal CSF OCB patterns have been reported in 70% to 80% of MS patients.
Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases, and therefore, this assay is not specific for MS
Reference Values
Only orderable as part of a profile. For more information see:
-OLIG / Oligoclonal Banding, Serum and Spinal Fluid
-MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid
Day(s) Performed
Monday through FridayReport Available
4 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83916
Specimen Minimum Volume
0.4 mL