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Test Code OCT2 OCT-2 Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Specimen Type: Tissue

Supplies: Immunostain Technical Only Envelope (T693)

Container/Tube: Immunostain Technical Only Envelope

Preferred:

-Formalin-fixed, paraffin-embedded tissue block

OR

-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: None


Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry (IHC)

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time
TECHONLY Ambient (preferred)
  Refrigerated 

Reject Due To

Wet/frozen tissue 
Cytology smears 
Nonformalin fixed tissue 
Nonparaffin embedded tissue 
Noncharged slides 
ProbeOn slides 
Snowcoat slides 		 Reject 

Clinical Information

OCT-2 is a transcription factor that binds to the octamer motif of the immunoglobulin gene promoter, recruits the coactivator BOB.1, and activates immunoglobulin gene transcription. OCT-2 is variably expressed in germinal center B cells, weakly expressed in mantle zone B cells, and weakly to moderately expressed in plasma cells. The protein is localized to the nuclear compartment. Expression of BOB.1, OCT-2, and PU.1 transcription factors are often downregulated in classical Hodgkin lymphoma. OCT-2 is overexpressed in lymphocyte-predominant (LP) cells of nodular LP Hodgkin lymphoma. These properties can be useful in the diagnosis of lymphoma.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.