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Test Code CCMVS Congenital Cytomegalovirus (cCMV), Molecular Detection, PCR, Saliva


Ordering Guidance


This test should be ordered to test saliva specimens from patients 21 days old or younger. To test saliva from patients older than 21 days, order CMVPV / Cytomegalovirus (CMV) Molecular Detection, PCR, Varies.

 

To test urine specimens from patients 21 days or younger, order CCMVU / Congenital Cytomegalovirus (cCMV), Molecular Detection, PCR, Urine. To test urine from patients older than 21 days, order CMVPV / Cytomegalovirus (CMV) Molecular Detection, PCR, Varies.

 

For CMV testing on plasma specimens, order CMVQN / Cytomegalovirus (CMV) DNA Detection and Quantification by Real-Time PCR, Plasma.



Specimen Required


Supplies: BD UVT with mini tip flocked swab (T971)

Collection Container/Tube: Flocked swab

Submission Container/Tube: Sterile, screw-capped, tube containing viral transport media with flocked swab containing saliva. See Collection Instructions for acceptable media.

Specimen Volume: 1 Swab in viral transport media

Collection Instructions:

1. Collect a saliva specimen using a flocked swab per swab manufacturer instructions.

2. Place in a sterile, screw capped tube containing BD Universal Viral Transport Medium (UVT) (1 mL or 3 mL), Copan Universal Transport Medium (UTM) (1 mL or 3 mL), Remel M4-RT, Remel M4, or Remel M6.


Method Name

Real-Time Polymerase Chain Reaction (PCR)

Specimen Type

Swab

Specimen Minimum Volume

Saliva swab submitted in minimum volume of 0.3 mL of viral transport media.

Specimen Stability Information

Specimen Type Temperature Time
Swab Frozen 7 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Clinical Information

Cytomegalovirus (CMV) is a double-stranded DNA virus of the Herpesviridae family. CMV is transmitted through direct contact from a variety of infected body fluids, as well as through sexual contact, organ transplantation, and intrauterine transmission during pregnancy.(1) CMV infection may be asymptomatic but can cause a wide range of symptoms in immunocompromised individuals. Congenitally acquired CMV (cCMV) may lead to long-term sequelae, including visual and hearing impairments, and cognitive and motor deficits.(2) Current recommendations indicate testing urine and saliva swabs for cCMV using a nucleic acid amplification detection method.(3)

Reference Values

Negative

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

87496