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HelpTest Code BNP B-Type Natriuretic Peptide, Plasma
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Plasma EDTANecessary Information
Include patient's age and sex.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot plasma into plastic vial. Freeze immediately or within 7 hours of collection.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma EDTA | Frozen | 365 days |
Reference Values
Males
≤45 years: ≤35 pg/mL
46 years: ≤36 pg/mL
47 years: ≤37 pg/mL
48 years: ≤38 pg/mL
49 years: ≤39 pg/mL
50 years: ≤40 pg/mL
51 years: ≤41 pg/mL
52 years: ≤42 pg/mL
53 years: ≤43 pg/mL
54 years: ≤45 pg/mL
55 years: ≤46 pg/mL
56 years: ≤47 pg/mL
57 years: ≤48 pg/mL
58 years: ≤49 pg/mL
59 years: ≤51 pg/mL
60 years: ≤52 pg/mL
61 years: ≤53 pg/mL
62 years: ≤55 pg/mL
63 years: ≤56 pg/mL
64 years: ≤57 pg/mL
65 years: ≤59 pg/mL
66 years: ≤60 pg/mL
67 years: ≤62 pg/mL
68 years: ≤64 pg/mL
69 years: ≤65 pg/mL
70 years: ≤67 pg/mL
71 years: ≤69 pg/mL
72 years: ≤70 pg/mL
73 years: ≤72 pg/mL
74 years: ≤74 pg/mL
75 years: ≤76 pg/mL
76 years: ≤78 pg/mL
77 years: ≤80 pg/mL
78 years: ≤82 pg/mL
79 years: ≤84 pg/mL
80 years: ≤86 pg/mL
81 years: ≤88 pg/mL
82 years: ≤91 pg/mL
≥83 years: ≤93 pg/mL
Females
≤45 years: ≤64 pg/mL
46 years: ≤66 pg/mL
47 years: ≤67 pg/mL
48 years: ≤69 pg/mL
49 years: ≤71 pg/mL
50 years: ≤73 pg/mL
51 years: ≤74 pg/mL
52 years: ≤76 pg/mL
53 years: ≤78 pg/mL
54 years: ≤80 pg/mL
55 years: ≤82 pg/mL
56 years: ≤84 pg/mL
57 years: ≤87 pg/mL
58 years: ≤89 pg/mL
59 years: ≤91 pg/mL
60 years: ≤93 pg/mL
61 years: ≤96 pg/mL
62 years: ≤98 pg/mL
63 years: ≤101 pg/mL
64 years: ≤103 pg/mL
65 years: ≤106 pg/mL
66 years: ≤109 pg/mL
67 years: ≤112 pg/mL
68 years: ≤114 pg/mL
69 years: ≤117 pg/mL
70 years: ≤120 pg/mL
71 years: ≤123 pg/mL
72 years: ≤127 pg/mL
73 years: ≤130 pg/mL
74 years: ≤133 pg/mL
75 years: ≤137 pg/mL
76 years: ≤140 pg/mL
77 years: ≤144 pg/mL
78 years: ≤147 pg/mL
79 years: ≤151 pg/mL
80 years: ≤155 pg/mL
81 years: ≤159 pg/mL
82 years: ≤163 pg/mL
≥83 years: ≤167 pg/mL
Day(s) Performed
Monday, Wednesday, Friday
CPT Code Information
83880
Clinical Information
B-type natriuretic peptide (BNP, formerly brain natriuretic peptide) is a 32-amino acid-ringed peptide secreted by the heart to regulate blood pressure, and fluid balance.(1) BNP is stored in, and secreted predominantly from, membrane granules in the heart ventricles and is continuously released from the heart in response to both ventricle volume expansion and pressure overload.(2)
The natriuretic peptide system and the renin-angiotensin system counteract each other in arterial pressure regulation. When arterial pressure decreases, the kidneys release renin, which activates angiotensinogen resulting in increased peripheral resistance of the arterioles, thus increasing arterial pressure.
The natriuretic peptides counteract the effects of renin secretion, causing a reduction of blood pressure and extracellular fluid volume.(3) Both BNP and atrial natriuretic peptide are activated by atrial and ventricular distension due to increased intracardiac pressure. These peptides have both natriuretic and diuretic properties: they raise sodium and water excretion by increasing the glomerular filtration rate and inhibiting sodium reabsorption by the kidney.
The New York Heart Association (NYHA) developed a functional classification system for congestive heart failure (CHF) consisting of 4 stages based on the severity of the symptoms. Various studies have demonstrated that circulating BNP concentrations increase with the severity of CHF based on the NYHA classification.(4-6)
Report Available
2 to 3 daysReject Due To
| Gross hemolysis | Reject |
Method Name
Immunoenzymatic Assay
Forms
If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen.