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HelpTest Code BHISC Bone Histomorphometry, Gross Microscopic Exam
Shipping Instructions
It is preferred that the specimen is shipped in 70% ethanol because it preserves the tetracycline label in the bone.
Necessary Information
Bone Histomorphometry: Patient Information (T352) must be completed and sent with the specimen. The laboratory requires this information in order to perform testing.
Specimen Required
Supplies: Metal Free Specimen Vial (T173)
Specimen Type: Bone
Preferred: Anterior iliac crest
Container/Tube: Metal-free specimen vial
Specimen Volume: Entire specimen
Collection Instructions:
1. Fix specimen in 70% ethanol.
2. Quantitation of bone turnover requires 2 time-spaced tetracycline labels.
3. The use of metal-free containers is required to avoid aluminum or iron contamination.
4. For complete instructions see Bone Histomorphometry Specimen Preparation (T579).
Additional Information: Consultation with a Mayo Clinic Laboratories pathologist or endocrinologist/nephrologist is recommended for first-time users of this service. Written instructions are available upon request.
Forms
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SS2PC | SpecStain, Grp II, other | No, (Bill Only) | No |
Testing Algorithm
Hematoxylin and eosin-stained slides are sent to pathology for review. Iron staining or aluminum staining may be performed at an additional charge.
Method Name
Histomorphometry
Specimen Type
VariesSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Varies | Ambient (preferred) | |
| Refrigerated | ||
Reject Due To
| Fixatives other than 70% alcohol Decalcified bone |
Reject |
Clinical Information
Bone histomorphometry is a very sophisticated procedure utilizing full-thickness bone biopsy.
Techniques such as 2-time interval labeling with tetracycline permit the direct measurement of the rate of bone formation. The information derived is useful in the diagnosis of metabolic bone diseases, including renal osteodystrophy, osteomalacia, and osteoporosis, and other disorders, such as aluminum toxicity and iron abnormalities.
Reference Values
A quantitative and interpretive report will be provided.
Day(s) Performed
Monday through Friday
Report Available
26 to 35 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
88346
88307
88313
Specimen Minimum Volume
5 mm bone